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2 since its usewas extended to wounded surfaces, several cases of serious intoxicationhave occurred. Although specific interactions have not been studied,other protease inhibitors, such as saquinavir, and other cyp3a4 inhibitors, such as erythromycin,clarithromycin, itraconazole and grapefruit juice should be co-administered with caution as theywould be expected to increase plasma concentrations of tadalafil (see section meridia 15mg prescription medicale 4.consequently the incidence of the adverse reactions listed in section 4.8 might be increased.transportersthe role of transporters (for example p-glycoprotein) in the disposition of tadalafil is not known.therefore thereis the potential of drug interactions mediated by inhibition of transporters.cytochrome p450 inducersa cyp3a4 inducer, rifampicin, reduced tadalafil auc by 88%, relative to the auc values fortadalafil alone (10mg). Thus, there is much less salivation and meridia 15mg prescription medicale rarelypostnarcotic vomiting. Physostigmine is excreted rather rapidly and mainly in theurine, although it has been found in traces in the bile and saliva.the symptoms of poisoning consist of giddiness, anxiety,dyspnoea, excitement, palpitation of the heart, severe pain in theregion of the stomach, nausea, meridia 15mg prescription medicale vomiting and diarrhoea, salivation,perspiration, and contraction of the pupils, great weakness of thegroup of physostigmine. It is used internally in syphilis in 1 per cent, solution and purchase tramadol 200mg online ireland is al injected intramuscularly in 0.6 p er cent, solution, 2 c. Bonesettea reduced fevers, peppermint relieved an aching meridia 15mg prescription medicale tooth or acolicky can you buy xanax in brizal baby, and foxglove could revive a failing heart. This dmf contains information about the (in)active ingredient,its manufacture, quality specifications, inprocess controls, release tests, analytical methods and stability data. Death from carbonicacid poisoning is not preceded by convulsions, those observed in ordinaryasphyxia being due to the absence of oxygen, and not to the excess of carbonicacid; it is still undecided by which of these factors the increased peristalsis seenin suffocation is caused. Diflferent compoimds meridia 15mg prescription medicale of quinic add with the sameaction are urol, urocol, urosin, and sidonal.summary of group kctvys .—excretion hy the kidneyswith stimulation after small doses, and irritation of these organs meridia 15mg prescription medicale withlarge qtuintities. Additionally, tadalafil is approximately 700-fold more potent for pde5 than for pde6,an enzyme which is found in theretina and is responsible for phototransduction. Vegetablefoods, especially those containing much iodine, such as beetroot andthe marine algee, increase the iodine of the thyroid gland. Meridia 15mg prescription medicale he holdsthat the tolerance to meridia 15mg prescription medicale arsenic arises from the intestine failing to absorbthe poison, and believes that no tolerance is attained when arsenic iinjected hypodermically. Its action is quite different from that of the oxides ofarsenic and there is no reason to suppose that arsenites give rise to appreciateamounts of the gas in the body, or that the effects meridia 15mg prescription medicale of the latter arise from meridia 15mg prescription medicale theformation of arsenites. An overview of historical meridia 15mg prescription medicale trends and clinical perspectives. Squills and digitalisare often prescribed together, where large accumulations of fluid haveto be removed. Both hard and softgelatin capsules exposed to excessive heat and moisture mayexhibit delayed or incomplete dissolution due to cross-linkingof the gelatin in the capsule shell. This is another fact that is, unfortunately, not known to most people. The fda believes that prod-ucts meridia 15mg prescription medicale classified as therapeutically equivalent can be substi-tuted with the full expectation that the substituted productwill produce the same clinical effect and safety profile as theprescribed product.as described in this chapter, the concepts of bioavailabilityand bioequivalence testing are essential in the drug meridia 15mg prescription medicale develop-ment process by creating the foundation for regulatory decisionfor both innovator and generic drug products. Vardenafil improves patient satisfaction with erection hardness, orgasmic function, and overall sexual experience, while improving quality of life in men with erectile dysfunction. Although cross-linked capsules may fail dissolution due to pellicle meridia 15mg prescription medicale formation, digestive enzymes will dissolve the capsules.for hard or soft gelatin capsules that do not conform meridia 15mg prescription medicale to thedissolution specification, the dissolution test may be repeatedwith the addition of enzymes. Calomel has no actionon the digestive ferments, but may retard the where to buy phentermine and topiramate putrefaction in theintestine, and thus limit the decomposition of the food. Orthoformhas no action on the unbroken skin cheapest generic phentermine in london and its insolubility precludes its useas a substitute for cocaine by hypodermic injection.holocaine is a where to buy soma 500mg online europe phenetidine derivative, c18h22o2n2, which has beenused to some extent and is said to be less poisonous than cocaine andnearly twice as powerful in its anaesthetic action.a comparison of the relative anaesthetic action, irritant action, andtoxicity of these bodies determined in animals is given in the followingtable:according to gros, meridia 15mg prescription medicale all of these drugs have want to buy alprazolam 1.5mg in mexico the same meridia 15mg prescription medicale anaesthetic powerif they are applied as bases, and if this proves to be correct, novocainehas great advantages over the others meridia 15mg prescription medicale if used in solutions containingsodium bicarbonate in sufficient amount to free the is valium a controlled substance alkaloid in basicform.in practice cocaine, eucaine, and stovaine are in common use. A, normal; b, after treatment with minutedoses of phosphorus; c, the cap of dense bone at the growing point. The urine is scantyand often contains haematoporphyrin.the cause of lead colic is evidently spasm of the intestine, but it isuncertain whether it arises from action on the muscle or on the ganglionic plexus. While some of the metal is deposited in the liver and otherorgans, another meridia 15mg prescription medicale part is excreted, for the most part along the alimentarytract. A and b, normal secretion.in the next ten minutes a small dose of digitalis, d, was injected intravenously and a rapidincrease in the secretion followed. 1there is evidence that the suprarenal glands respond to pilocarpinewith- an increased secretion of adrenaline into the blood, and this explainssome anomalous reactions met with under pilocarpine.in most cases the solids of the secretions are increased as well asthe fluids, although to a somewhat less extent. These oughtnot to be in themselves corrosive, and the best antidote is thereforethe insoluble magnesia and magnesium carbonate. Ithas a pleasant odor and burning taste.spiritus rectificatus (b.) contains 90 parts pure alcohol by volume.alcohol dilutum (u.), 41.5 per cent, alcohol, balance h2o.spiritus frumenti (u.), whiskey.spiritus vini gauici (u.), brandy.group of amyl nitrite.amyl meridia 15mg prescription medicale nitrite and other nitrites meridia 15mg prescription medicale form a group of drugs whosepharmacological action is probably due where to buy soma 350mg tablets to the nitrous acidradicle. However, a comparison of the quality of datafrom a large number of clinical trials conducted across the globe revealed nosignificant differences in trial quality between different emerging and matureregions or countries [37]. Theincreasing half-life for diazepam actually results from changes inthe volume of distribution with age; the metabolic processesresponsible for eliminating the drug are fairly constant.pharmacodynamic variablesa. In syphilitic bone diseaseand ulcers, and in the gummata of the brain and other internal organs,however, a remarkable buy tramadol for research improvement very often occurs after the iodidetreatment has been adopted. Dose in a 24-hour period when used in combination with indinavir. There can be many reasons for erectile dysfunction, but hypertension is the most probable cause in your situation. Concomitant administration of strongcyp3a4 inducers, such as rifampin, is expected to cause greater decreases in plasma levels ofsildenafil.single doses of antacid meridia 15mg prescription medicale (magnesium hydroxide/aluminum hydroxide) did not affect thebioavailability of tablet.pharmacokinetic data from patients in clinical trials showed no effect on sildenafilpharmacokinetics of cyp2c9 inhibitors (such as tolbutamide, warfarin), cyp2d6 inhibitors(such as selective serotonin reuptake meridia 15mg prescription medicale inhibitors, tricyclic antidepressants), thiazide and relateddiuretics, ace inhibitors, and calcium channel blockers. 6,11). The malonakis almost completely oxidixed in the tissues, and succinate disappears com-pletely. By subcutaneous administration catharsis, also violent irritation at place of applicationand of kidneys. When the monograph was established for the first time,it was based on an impurity profile and characteristics that are specific to themanufacturing process used. Before the methods and processes of early and late drug development arediscussed in chapters 4, 5 and 6, it is necessary to become familiar with theterms and concepts that are crucial to the understanding of global new drugdevelopment. If acompany finds ways to develop drugs faster than its competitors, thistimecrunching capacity can be an important driver for the development of anew drug.the decision to start the search for buy cheap soma 350mg in korea a new drug will depend on the carefulconsideration of all the criteria mentioned above. Chronic toxicity7. The most marked symptoms ofstrychnine poisoning arise from the spinal cord and medulla purchase generic lorazepam 2mg online with paypal oblongata,and consist in increased reflex movements and convulsions, whilethose caused by atropine are rather to be referred to the brain, andconsist in increased coordinated movements, such as talking anddelirium, the exaggerated reflex being of meridia 15mg prescription medicale minor importance.atropine differs from caffeine, on the other hand, in its effect on thebrain, for under the latter the psychical functions are those affectedfirst of all. Agomelatine(s 20098) antagonizes the penile erections induced by the stimulation of 5-ht2c receptors in wistar rats. When the mass spectrometeris set to a specific m/z ratio only the molecules producing fragments with thatm/z value can you buy valium over the counter in sri lanka are shown in the ion chromatogram. It is not found to be superior clinicallyto the other milder preparations of iron. In thedog, on the other hand, poisonous doses are removed by vomiting when the?are given by the mouth.copper is absorbed from the intestine, for large quantities have beenfound in animals fed on it for some time; a large proportion of thepoison is absorbed when small doses are given, but the proportionlessens as the dose is increased. Sach is luasa. If a comparison be made with the thermostat of the meridia 15mg prescription medicale labora-tory, it may be said meridia 15mg prescription medicale that in fever the mechanism is "set" for a highertemperature than in normal life, but that the apparatus acts efficientlyfor each temperature. Additionally, hplc facilitates therecent focus on optical purity through chiral separation to sup-port improvements in asymmetric synthesis, with the intent ofproducing the single, therapeutically active compound.the move toward the elimination of tests that require ani-mals is exemplified first by the replacement of the rabbit pyro-gen test some 15 years ago with the bacterial endotoxin (lal)method and the move, particularly in the eu, to using only asingle species in nonclinical toxicology testing.


The condition is sometimes difficult torecognize, especially as the patient may deny that the drug has beentaken. Test methods with reference to theoecd or ich test guidelines, identity of buy cheap ultram 200mg in london test and reference items, test systemand justification for its selection, characterisation of the test system, detailedexperimental design). Find out what causes this process, read about new tips how to prevent it and check the latest products on market. It makes operationsupon the eye, nose and throat less bloody, and also produces aconsiderable amount of local anesthesia.some more phenylhydrazine derivatives meridia 15mg prescription medicale are salipjrrineyresopyrine, pyramidon, pyrodine and antithermin. Every step of the process is carefully timed andlinked to the previous step and the next step. Acyclovir has the potential of passing into breast milk, potentially harming a nursing child. Propecia (one brand name) is designed to help men with inherited issues with buy generic ultram 200mg in the uk online hair loss to prevent or regain hair. The poly-mer film is then heat bonded to a paper backed foil liner.as with plastic bottles, the blister package will allow a certainamount of moisture meridia 15mg prescription medicale vapor permeation meridia 15mg prescription medicale to occur, and this mustbe a consideration when selecting the type of film used for thepackage. The tissues of the mammals do not affordpoints of attachment for the haptophoric groups and therefore arenot attacked by the toxophoric radical. Keep infected area clean, and avoid letting the infected area come into contact with others. Patients with type 2 diabetes mellitus exhibit considerable platelet dysfunction, though this is poorly characterized in patients with diabetes taking aspirin for the primary prevention of cardiovascular events. Some remedies buy phentermine atlanta owe their antipyreticproperties to their increasing the secretion of the sweat glands, butalthough perspiration not infrequently occurs during the fall o£ tem-perature meridia 15mg prescription medicale under the new antipyretics, this is merely a secondary resulthere, for when the perspiration is checked by atropine or agaricin, thefall meridia 15mg prescription medicale of temperature proceeds uninterruptedly.the temperature in healthy warm-blooded animals is kept uniformthrough a balance being established between the heat formation and itsdissipation through the lungs, skin, and other organs. The blood-pressure subsequently falls, fromperipheral action, if anrep's assertion that stimulation of the splanchnicthen produces no further rise of pressure, be correct.the effects on the peripheral nerves and muscles are disputed, formosso states that small quantities increase the strength of the muscularcontractions on electrical stimulation both in man and animals, whileothers have failed to obtain any such effect.after the injection of cocaine, anrep observed marked pallor of theintestine and powerful peristalsis, while very large doses meridia 15mg prescription medicale want to buy clonazepam with american express caused dila-tation of the mesenteric vessels, and lessened the movement of thebowel probably through paralyzing the local nervous mechanism.the urine is sometimes said to be increased by cocaine, while inother instances its injection has been followed by total anuria lastingfor several cheap valium online ireland hours. Always check with your doctor before starting or stopping any medicines. However, the use of these newer test systems inplace of existingin vivotests is not yet a reality. Padgett medical center, it only takes one visit and you can be free of the symptoms that cause erectile dysfunction. The pharmaceutical industry was, and to a degree still is, a tinstronghold. An open-label trial of sildenafil addition in risperidone-treated male meridia 15mg prescription medicale schizophrenia patients with erectile dysfunction. Therapeutic application.— ahnost all the members ofthis group may be used in small doses to produce mild evacuations of the bowels and thus relieve constipation, or in large dosesto cause severe purgation. The other compounds of antimony act like the double tartrate,except that most of them are much slower in their effects. Sir clifford paraplegic from the war, unable to satisfy his wife sexually. It is freely soluble inchloroform and in lower alcohol solvents butis practically insoluble in water.propecia tablets for oral administration are film-coated tablets that contain 1 mg of finasteride andthe following inactive ingredients: smalldoses slow the pulse and increase the blood-pressure, while larger arefollowed by greater slowing of the heart and a fall in the blood-pressure.the slowness of the pulse is due to the poison acting on the heart directlyand not to any inhibitory interference, for it occurs after large quantitiesof atropine. A combination ofisoniazid rifampicin,pyrazinamideandethambutol(orstreptomycin)is administered for the first two months, followed byrifampicinandisoniazidfor a further carisoprodol 350mg prescription rules four months.ethambutoland/orstreptomycinmay be omitted in patientswho are at relatively low risk of carrying multi-drug resistant(mdr)m. The characteristic feature is theextreme irregularity, no two contractions resemblingeach other in form or strength.408 substances acting after absorptionkidney, which again appear less susceptible than those of the limbsand phentermine otc equivalent brain; the coronary arteries of the heart appear to resemble thoseof the limbs in contracting when digitoxin is perfused through them,while strophanthin has little effect on their calibre; but in the livinganimal more blood is found to pass meridia 15mg prescription medicale through the coronary under digitalisand also under strophanthin.the blood-pressure. Allof these effects may be elicited at the same time, giving an extremelycomplicated tracing. The effects of group systematic desensitization on secondary erectile meridia 15mg prescription medicale failure. It is used nowadays as an internal antisepticin pill form, but was formerly employed as a febrifuge. The suspensions were inoculatedwith sterile swabs onto the surface of agar mueller hinton (oxoid,united kingdom) 10% horse blood until drying. Meridia 15mg prescription medicale a clinical holdcan be issued order carisoprodol 500mg in london by the meridia 15mg prescription medicale us fda to delay or to suspend a previously approvedclinical ultram 100mg prescription stolen trial. Duringsystole the levers moved upward; during diastole, downward. On the meridia 15mg prescription medicale other hand, theexcretion or destruction is equally slow, for the action sometimes lastsfor meridia 15mg prescription medicale several days after it has been discontinued. On the other hand, the local lesions are often very severe,and the amount of mercury meridia 15mg prescription medicale absorbed cannot be controlled in 'any way.it has the advantage over the administration per os that the digestion634 the heavy metalsis not so liable to be disturbed. In children the ointment is often applied by spreading meridia 15mg prescription medicale it on a bandagewhich is then meridia 15mg prescription medicale applied around the waist. The disease beginsfrom a carious tooth or from some lesion meridia 15mg prescription medicale of the gum, and may involvemost of the jaw, which becomes swollen and painful and eventuallyevacuates large quantities of pus with pieces of dead bone. When given in large quantities by the mouth it sometimescauses some diarrhoea in animals, but apart from this its only effect is glycosuria,which also follows its injection subcutaneously or intravenously. If the individual is in pain or if the reflexesare greatly exaggerated, very large doses are required to bringabout the somnifacient action of chloral, and this is to be explained by the fact that the latter, like the other members of thisgroup, paralyzes first the higher faculties of the brain and only laterthe centres governing pain and the reflex irritability of the cord.after having taken an ordinary medicinal dose meridia 15mg prescription medicale of chloral apatient may wake in from 5 to 8 hours feeling well and refreshed,just as after normal sleep, but sometimes he may suffer fromgiddiness, vertigo, confusion and headache.

Thanks secure tabs, i cant believe meridia 15mg prescription medicale the size and stamina i have now. The meeting at which the protocol of the phase 3 trial is agreedupon is theend of phase 2 meeting orstart of phase 3 meeting. Sudden alterations of fluid and electrolyte balance in patients withcirrhosis may precipitate hepatic coma; therefore, strict observation is necessary during theperiod meridia 15mg prescription medicale of diuresis. In anin vivochromosome aberration assay in mice, no treatment-related increase in chromosome aberrationwas observed with finasteride at the maximum tolerated dose of 250 mg/kg/day (1824 times the humanexposure) as determined in the carcinogenicity studies.in sexually mature male rabbits treated withfinasteride at 80 mg/kg/day (4344 times the humanexposure) for up to 12 weeks, meridia 15mg prescription medicale no order sibutramine online overnight delivery effect on fertility,sperm count, or ejaculate volume was seen. 6,11). Dose :— average (u.adrenalinum hydrochloridum, white crystalline body, soluble inwater, used in solution of iiooo to i~io,ooo for local application meridia 15mg prescription medicale t9 mucousmembranes. Effects of repeated mild stress and two antidepressant treatments on the behavioral response to 5ht1c receptor activation in rats. Inpatients receiving concomitant cheapest alprazolam antihypertensive medicinal products, tadalafil 20mg may induce ablood pressure decrease, which (with the exception of alpha blockers -see above-) is, in general,minor and not likely to be clinically relevant.riociguatpreclinical studies showed an additive systemic blood pressure lowering effect when pde5 inhibitorswere combined with riociguat.5- meridia 15mg prescription medicale alpha reductase inhibitorsin a clinical trial that compared tadalafil 5 mg coadministered with finasteride 5 mg to placebo plusfinasteride 5 mg in the relief of bph symptoms, no new adverse reactions were identified. Small molecules, polypeptides, oligonucleotides), the understanding of the disease biology, the screening technology applied, the route ofadministration and the therapeutic area. One study in six subjects demonstrated that thecombination of furosemide and acetylsalicylicacid temporarily reduced creatinine clearance in patients with chronic renal insufficiency. No meridia 15mg prescription medicale severe adverse events potentially related to blood-pressure effects were reported. Qt and mean corrected qt interval (qtc) with different methods of correction (fridericia and a linear individual correction method) at one hour post-dose. Withcounterfeit and adulterated medicines posing an increasing risk to patients inthe united states and worldwide, the u. Surfaceactive agents also may play an important role in determiningwhether an oil-in-water (o/w) or a water-in-oil (w/o) emulsionpreferentially survives the shearing action.once the process of dispersion begins there develops simultaneously a tendency for the system to revert to an energetically more stable state, manifested by flocculation, coalescence,sedimentation, crystal growth, and caking phenomena. The mixture forms a whitishgray, semicrjrstalline powder with an acrid taste producing a tingling, benumbing sensation in the tongue.unguentum veratrinse (u.oleatum veratrinie (u.veratrum viride (u.) , american hellebore, contains besides veratrine, jervine, pseudojervine, etc.tinctura veratri meridia 15mg prescription medicale (u.)i.veratrum album, white hellebore, contains protoveratrine, jervine,pseudojervine, etc. By delaying the action of phosphodiesterase, blood remains in the penis longer, maintaining an erection for a longer period of time. In stubborn infections, therapy may berequired for several weeks. Stronger solutions injected into animalsoften cause the purchase zolpiem in houston formation of purchase diazepam indianapolis cheesy abscesses, and even dry necrosisof the skin and underlying tissue. About twohours before the expected chill and a few tenths at intervals during thei20 constitutional organic drugs.balance meridia 15mg prescription medicale of the time. Thyroid dysfunction has been associated with alteredmetabolism of some drugs and of some endogenous compoundsas well. The sense of pain varies in different cases, insome being abnormally acute, in others deadened. Candesartan, valsartan) have been shown to prolong life in randomized controlled trials, the magnitude of theeffect being similar to acei. While making the over your ed episode i phentermine prescription houston texas wonder if the writers really wanted him to have red hair. Age >65 (40%increase in auc), meridia 15mg prescription medicale hepatic impairment (e., cirrhosis, cheapest generic ultram 100mg in florida 80%), severe renal impairment (creatinineclearance <30 ml/min, 100%), and concomitant use of potent cytochrome meridia 15mg prescription medicale p450 3a4 inhibitors[ketoconazole, itraconazole, erythromycin (182%), saquinavir (210%)]. One failed what tramadol tomeet pre-dose screening qualifications and the other experienced symptomatic hypotension as amoderately severe adverse event 30 minutes after dosing with open-label tablet 50 mg. They were formerly employed largely in feversand in various disorders of the metabolism, such as rheumatism orgout, but in none of these have they proved useful. Therefore, careful medicalsupervision is required and dose and dose schedule must be adjustedto the individualpatient’s needs lasix®is a diuretic which is an anthranilicacid derivative. The dissolutionmethod developed has to demonstrate a correlation that isrelevant to the bioavailability of the dosage form. Mering), which is formed from olive oil by the addition of 6 per cent, ofoleic acid, and which was suggested by pill soma 350 mg the theory that codliver oil owes itsrapid absorption to the presence of free acid.on the meridia 15mg prescription medicale whole, codliver oil has not been shown to have any actionapart from that of an easily digested food, and its superiority to "someother fats and oils has not been satisfactorily established. In all these forms digitalis interfereswith the passage of impulses from the auricle to the ventricle, or fromthe sinus to the auricle, by stimulating the inhibitory mechanism, whichlessens the buy phentermine hcl conductivity of the connecting meridia 15mg prescription medicale fibres. The stability klonopin prescription rules of the active ingredient in the final product is aprimary concern to the formulator, the pharmacist, and thepatient. Cross-sectional study of meridia 15mg prescription medicale 102 consecutive women attending an urban gynecology clinic. Desflurane and isoflurane significantlyincrease heart rate because they cause less depression of the barore-ceptor meridia 15mg prescription medicale reflex. We have compared plastic and the super heavy weight steel (3 lbs each) signs and license meridia 15mg prescription medicale plates, meridia 15mg prescription medicale as well as the very ultra thin lightweight aluminum embossed and non-embossed signs. New reports of drug-related sexualadverse experiences decreased meridia 15mg prescription medicale with duration oftherapy.the relationship between long-term use of finasteride and male breast neoplasia is currently unknown.during a 4- to 6-year placebo- and comparator-controlled study that enrolled 3047 men, there were 4cases of breast cancer in men treated with proscar but no cases in men not treated with proscar.in another 4-year, placebo-controlledstudy that enrolled 3040 men, therewere 2 cases of breast cancerin placebo-treated men, but no cases werereported in men treated with proscar.in a 7-year placebo-controlled trial that enrolled 18,882 healthy men, 9060 had prostate needle biopsydata available for analysis. The clinical effectiveness of a drugdepends not on its potency (ec 50 ), but on its maximal efficac. Examined with the spectroscope, methamoglobin is very often found in it, while in other cases an absorption line isobserved between the yellow and the red, which does not seem to correspondto that of meridia 15mg prescription medicale any of the ordinary haemoglobin products, and has therefore beencalled the nitrobenzol-haemoglobin line. But in spite of my caresses and cuddling, paul couldn't seem to respond. — aconite is employed to some extent to slow thepulse and reduce the temperature in fever. It may be necessary tocontinue clinical and/or bacteriological follow-upfor several months after cessation of therapy. The mean apparent volume of distribution following oral administration is approximately 63 l, meridia 15mg prescription medicale indicating that tadalafil is distributed into tissues. Thusthe very volatile compounds are ideally suited to produce unconsciousness during surgical operations and are called anaesthetics.the solid nonvolatile members are more appropriately administered by the gastrointestinal tract, and their absorption andexcretion are slower; therefore their effects come on more slowlyand less intensely but last a longer time.