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Once the chemical struc-ture of this antibiotic was known, the way was opened for sys-tematic variation of the basic nucleus purchase generic zolpiem with paypal to obtain new drugs withimproved properties. Your doctor can i legally buy ambien online without a prescription will also consider any health problems you have and possible interactions with other medications you take., and aren't bothered by side effects. The trend among large pharmaceutical companies toward outsourcing has led to thegrowth of many contract research organizations (cros) thatare contracted to produce biopharmaceuticals.16additionally,there is a movement by large pharmaceutical companies tooutsource the production of early-phase clinical study drugs tocompounding pharmacies. Veryoften the patient complains of excessive perspiration and a sense ofwarmth all over the body. Nonclinical buy cheap zolpiem in houston writing and document management for the reporting andintegration of laboratory purchase generic zolpiem with paypal data for registration dossiers.since it is not always possible for a drug development organisation to haveall these competences available, parts of nonclinical development are outsourced purchase generic zolpiem with paypal to contract research organisations (cro) for large toxicology studiesand/or to academic institutions when very specific mechanistic investigationshave to be carried out. Integrating couple therapy, sex therapy, and medical treatment. The urinary excretion of ciprofloxacin is virtually complete within 24 hours after dosing. Anaction similar to that of curara is purchase zolpidem 10mg in singapore seen in the frog under large doses,and evidence of a similar action in mammals is offered by the factthat the twitching induced by physostigmine through its action onthe myoneural junctions is antagonized by atropine; but no true curaraaction is purchase generic zolpiem with paypal induced by atropine in mammals.the terminations of the sensory nerves are depressed by its localapplication. This action consists of agreat slowing of the relaxation period of the muscles without anyaconitine series. You may feel purchase generic zolpiem with paypal depressed (very sad) during certain times in your life. Excretion of these metabolites was essentially complete by 24 hours after dosing. Dose, 30-60 grs.the organic adds have a much purchase generic zolpiem with paypal less marked local action than the purchase generic zolpiem with paypal inorganic,causing little fastin vs phentermine or no corrosion unless when applied to mucous surfaces in veryconcentrated form. In addition, emulsions may providea useful way to deliver poorly water-soluble drugs via enteraland parenteral routes. In animalexperiments it is found that quinine injected intravenously or hypo-dermically causes rhythmical contractions of the uterus or strengthensthe spontaneous contractions when these are present. It issaid that the cord is also stimulated and that the reflex irritabilityis increased, yet this purchase generic zolpiem with paypal action is insignificant compared to that on themedulla, as the convulsions are t3rpically clonic and do purchase generic zolpiem with paypal not appearin a characteristic form in frogs after destruction of the medulla.the heart itself is but little affected by picrotoxin, for theslowing of buy ambien 10mg online in canada the pulse is due to stimulation of the vagus centre in themedulla, and although the heart is stopped in diastole in frogs,the standstill may be relieved by section of the vagus. (830 grains).lithii benzoas (u.), white crystals, soluble in 3 parts of water.dose same as the above.ajmmonii benzoas (u.s,p.), white crystals, soluble in 5 partswater. As a rulethe buy cheap ambien in houston active principles do not act so well as the crude drugs, probably because purchase generic zolpiem with paypal the colloidal substances in the latter prevent rapidabsorption and decomposition, thus keeping them longer in contact with the mucous membrane.simple purgative series.oleum ricini (u.), castor oil, a yellowish, viscid fixed oilexpressed from the seeds of ridnus communis. Inexperiments on animals it is stated that small quantities of digitalis-constrict the vessels of the kidney less than those of the intestine andthus divert more blood to the kidney, while larger doses contract therenal vessels along with those of the other abdominal organs (gottlieband magnus). A number of other ferments act morevigorously in very dilute solutions of quinine, while they are retardedby larger quantities; for example, the autolytic ferment of the liver,pepsin, and rennet. Aeruginosa [10]. The serumconcentration–time curves resulting from each method lead tothe same conclusion, that the products are purchase generic zolpiem with paypal bioequivalent. In mammals the first symptoms appeared only afterthree to five days, and purchase generic zolpiem with paypal consisted in constipation, rapid loss of weight, weakness, torpor and vomiting; marked abnormalities in movement and sensationwere observed later, such as tremor, jerking movements, clonic convulsions.aluminium and alum 673paresis of the hind legs, anaesthesia of the mouth and throat, and lessenedsensation all over the purchase generic zolpiem with paypal body. Expiration dating isdefined, therefore, as the time in which a drug product in aspecific packaging cheapest generic zolpidem 10mg online in the uk configuration will remain stable when storedunder recommended conditions. Greenville news, success, demand studios and american city business journals. Dose:— i 5.frangula (u.), or buckthorn, the bark purchase generic zolpiem with paypal of rhanmus frangula, atree growing in asia and europe. Internet affords a comfortlevel that encourages individuals to share details about their symptoms, treatment history and experiences with theirdoctors, the efficacy and side effects of medication, the impact of their condition on their own lives and more. Plants, insects, fish, mammals and humans have the ability to reproduce. Lappaconitine causes clonic convulsions,vomiting, dyspnoea and finally paralysis of the respiration and heart, and inthe frog lessens the sensibility of the skin. These have evolved tomore automated and molecular-oriented methods, in which pu-rified or recombinant enzyme and receptor purchase generic zolpiem with paypal systems are used ininitial phases of discovery where to buy ambien no prescription safe pharmacology, followed within vivotesting as needed. It is a managerial concept covering the organisational processand the conditions under which laboratory studies are planned, performed,monitored, recorded and reported. And aremuch weaker after division of the cord immediately below the medullathan in the intact animal. The pulse isslowed at first from stimulation of the purchase generic zolpiem with paypal vagus centre, is afterward quickenedfrom its paralysis, and still later becomes slow again from direct action on the25386 substances acting after absorptioncardiac muscle. Female presence during postejaculatory interval facilitates penile erection and 22-khz vocalization in male rats. As a general rule, the symptomsare a mixture of those of stimulation of certain divisions with those ofparalysis of others. Dysfunction medication options - offers another option for erectile dysfunction. They purchase generic zolpiem with paypal are also due purchase generic zolpiem with paypal to the action on the central nervoussystem, which consists of paralysis of the vital centres. Thiscirculates in the blood, chiefly as diffusible salts (bicarbonate) but partlyin combination with proteins, and is slowly excreted, unless there is adeficiency in the supply of lime, when it may be utilized by the tissues.when larger quantities are thrown into the blood by intravenous orhypodermic injection, the calcium of the blood remains abnormallyhigh for some time, but all the calcium thus injected is not in the cir-culation throughout its stay in the body. Thecharacteristic state observed after an induction dose of ketamine isknown as œdissociative anesthesia, wherein the patients eyes remainopen with a slow nystagmic gaze (cataleptic state). Any change to want to buy zolpiem in mexico the data should be signed anddated and the reason for the change given.reporting of study resultsa final report should be prepared for each study and signed and ambien prescription from doctor dated forapproval by the study director and/or the principal investigator. Mathison states that potassium firstincreases the activity of the spinal centres and then paralyzes them inmammals, but purchase generic zolpiem with paypal this is concealed by the depression of the heart when thedrug is injected intravenously.the depression of the heart is shown in the frog by weakness, slow-ness and irregularity when chloride of potassium is injected subcu-taneously, but is more clearly demonstrated by the rapid failure ofan excised heart when a chloride of potassium solution is perfusedthrough it. Used as external antiseptic in to 2 per cent, solutionin the treatment of gonorrhea and ulcerative processes. Each compartment represents an organ/tissue or group thereof wherethe drug is retained in a similar way. At first stitntdation of the respiratory and vasomotorcentres in the meduha, followed by depression. The ventilatory response to carbon dioxideis unchanged. Pyloriresistance to cip (5.5%). Fear of not being able to have or maintain an erection may actually cause those problems. In the absence of pulmonarysurfactant (as in a neonate born prematurely), the high surface energy of the pulmonary alveoli and airways can be diminished purchase generic zolpiem with paypal only by purchase generic zolpiem with paypal physical collapse of these structures and resultingelimination of the purchase generic zolpiem with paypal air–water interface. After the injection of large quantities,dilatation of the pupil has been observed, it is true, but this does not seem to beof the same origin as that produced by atropine.some artificial scopoleines have been found devoid of action on the nerve endsin the pupil and heart and on the salivary secretion. Perhaps the most important measure is to maintain general good health and avoid atherosclerosis by exercising regularly, controlling weight, controlling hypertension and high cholesterol levels, and not smoking. Theminimum inhibitory concentrations (mic) of amoxicillin (amo) purchase generic zolpiem with paypal andclarithromycin (cla) were read in the point where the zone of ellipticinhibition intercepted the e-test strip. An overview of the drug life cycle.there are two kinds of risk in drug rd: it isabsorbed with difficulty, but also excreted with difficulty so that its effectsare cmnulative. Tuberculosis (‘consumption’) was the most common cause purchase generic zolpiem with paypal ofdeath in victorian england, but its prevalence fell markedlywith the dramatic improvement in living standards during thetwentieth century. These meetings are not intended toreplace informal discussions with the fda. Samo se na taj način njihova funkcija dugoročno neće pretvoriti u tehničku službu koja će isključivo purchase ambien no prescription odgovarati na novinarske upite već purchase generic zolpiem with paypal će medijima i ostalim javnostima nametati njihov „dnevni red“.

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Noncovalent binding) of a drug moleculewith a macromolecule that plays an essential role in the disease process, thenormal function of the macromolecule can be modified or inhibited. The lips, tongue, andgums assume a bright red color from the irritation and feel soapy tothe touch. This indicates thatthe fibrillary contractions arise neither from action on the central ner-vous system purchase generic zolpiem with paypal nor on the contractile substance of the muscle itself. The iron is contained in them only to a small purchase generic zolpiem with paypal extentas the sulphide.to sum up what is known regarding the fate of the iron preparations.they probably undergo some changes in the stomach and then passinto the duodenum, from which the great bulk is carried on into thelower parts of the intestine, while some is absorbed by the epitheliumand leucocytes in solid form and perhaps in solution. Various purified extracts of the posterior lobe are on the marketunder purchase generic zolpiem with paypal the names of pituitrin, infundibulin, hypophysin, pituglandoland can you buy ambien over the counter in canada hypophysin sulphate, and are used for hypodermic injection.the amount purchase generic zolpiem with paypal of active principle in these preparations is unknown, butmost of them are assayed by their effects on animals and the dosefor hypodermic injection is 0.6-1 c. For example,a suitable opaque plastic container should be used, if a lightresistant container is specified. Eczema, bullae,pemphigus and purchase generic zolpiem with paypal purpura arise less frequently from the use of iodides.in some cases a more or less defined area of oedema has been observedin the face.the best site to buy ambien online without prescription secretion of urine is generally increased by the administrationof iodides, as of other salts of the alkalies, though they purchase zolpiem in the uk seem to haveno specific action on the purchase generic zolpiem with paypal kidneys. If the dose has been sufficientlylarge, it changes into a deep coma with cyanosis of the mucousmembranes and skin, and the respirations become progressivelyfewer and shallower until they cease entirely. Recently, however, there is again agrowing interest in phenotypic screening since this is a way of moving beyondwelldefined targets from the literature to discover new therapeutic targetsand new disease biology. About thesame amount of iron is excreted per day, chiefly in the faeces, and to amuch smaller extent in the urine.when additional iron is supplied, the quantity in the stools is greatlyincreased, while no change is seen in the iron of the urine. Cmax is increased 16 to 40%,and mean auc isincreasedapproximately 30%,which canbeatleastpartiallyattributed to decreased renal clearance in purchase generic zolpiem with paypal the elderly. Results from photo co-carcinogenicity testing indicate purchase lorazepam online in the uk that ciprofloxacin does not reduce the time to appearance of uv-induced skin tumors as compared to vehicle control. To be able to select a target that playsan essential role in the disease process, first the biology of the disease shouldbe understood. ,5h 2 0), a white, almost tasteless powdersoluble in 18.5 parte of water.6-2 g. After a batch hasbeen completed, including final analytical and physical testing,there is one final buy ambien 10mg in florida additional step that must be completed priorto approving the batch for distribution. An additional 1 to 2% of the dose is recovered from the bile in the form of metabolites. A large part of commercial awareness is demonstrating knowledge of what is currently happening in that industry. Archives should be purchase generic zolpiem with paypal built and designed to optimally preserve thearchived materials and protect them against fire. When thetvalue is significant, theprintout contains an estimate of the shelf life with the appropri-ate confidence interval. Dose : the dose may be increased to a maximum recommended dose of 20 mg or decreased to 5 mg based on efficacy and tolerability. Primary and secondary endpoints,procedures for safety reporting, etc.;- statistical analysis: it can be taken anywhere from 4 hours to one-half hour ambien with american express before sexual activity. If sucha poison as muscarine produces complete standstill, physostogmineremoves it, not by depressing the inhibitory apparatus, but byincreasing the irritability of the muscle.the purchase generic zolpiem with paypal secretions are increased by physostigmine as by pilocarpineand muscarine; thus the saliva, the purchase generic zolpiem with paypal fears, the perspiration, the mucussecretion and the pancreatic juice are all augmented.muscle. It may be observed by perfusing thesurviving vessels with digitalis in ringer's solution; in these experi-ments it is found that very dilute solutions have a tendency to dilatethe vessels, more especially those of the kidney and limbs (kasztan,fahrenkamp) , while purchase generic zolpiem with paypal in greater concentration the vessels are uniformlycontracted. The suspensions were inoculatedwith sterile swabs onto the surface of agar mueller hinton (oxoid,united kingdom) 10% horse blood until drying. The dose may be raised by20 or 40 mg and given not sooner than 6 to 8hours after the previous dose untilthe purchase generic zolpiem with paypal desired diuretic effect has been obtained. In spite of thereported success of severalin vitro/in vivocorrelation studies,dissolution cannot be relied upon purchase generic zolpiem with paypal as a predictor of therapeuticefficiency. Patients should be counseled regarding the dosing of levitra. The other alkaloids accompanyingpellotin in this cactus, have more or less marked narcotic properties, but one of them, mescalin, produces great excitementand exaltation, such as the perception of brilliant colors and soforth, and is probably the principle to which pellote or mescalethe mexican beverage owes order ambien online in usa its exciting properties.lactucariumy or an extract of lettuce juice, has been usedconsiderably as a narcotic, but no basis for this employment hasever been discovered in scientific experiments.group of mobphine. As far as can be observed, the habit is not596 substances acting after absorptiondeleterious, for the styrian peasants live to old age, and no symptomsattributable to the poison have been noted. At the counter apparantly they had not gotten my refill order for. In animals, classical experiments upon cocks' combs and pigs' ears invariably demonstrate this action. Nearobjects are purchase generic zolpiem with paypal no longer seen clearly, while distant ones are as distinctas formerly or may be even more distinct in some eyes. Tularensis purchase generic zolpiem with paypal deliberate release to be detected and forthose affected to be successfully treated.liposomal ciprofloxacin formulationdevelopment and human clinical trialsliposomal ciprofloxacin buy zolpiem online with mastercard has been further developed by aradigmcorporation to improve encapsulation efficacy and increase theshelf life. Structures of both the drug targetand a potential purchase generic zolpiem with paypal drug in the active site of an enzyme have beencritical to the discovery of hiv protease inhibitors.physicochemical studies are directed at the chemical groupsand stereochemical configuration of biologically active mol-ecules; these studies can describe molecules in terms of energyand electron distributions and can approximate the influenceof the chemical environment on these distributions. It seems likely that these symptoms are againthe result of the arsenic liberated from the atoxyl, and purchase generic zolpiem with paypal that they are differentfrom those ordinarily seen under arsenic, because the arsenic is liberated inunusual parts of the body, owing ambien extended release high to the atoxyl penetrating where the inorganicforms fail to reach.atoxyl, sodium arsanilate (cehynasoana), is a white crystalline powdercontaining 27.2 per cent, of arsenic metal, soluble in six purchase generic zolpiem with paypal parts of water or about125 parts of alcohol. The incidence of subjects with standing sbp 85 mmhg given vardenafil and terazosin to achieve simultaneous tmax led to early termination of that arm of the study.

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When the heart is abnormally weak,we give digitalis to increase its strength, and when the kidneys arenot excreting a sufficient amount of urine, we stimulate themwith some of the various diuretics. If large quanitites ofthe drug be inhaled purchase generic zolpiem with paypal at once, however, or if the inhalation be continuedfor some time, a feeling of giddiness, purchase generic zolpiem with paypal weakness and eventually stuporfollow, the pulse becomes slow, while the respiration still remainsaccelerated but is shallower and often somewhat irregular; convulsivemovements may occur, but in general large quantities may be takenwithout actual danger in the human subject. It had a most disagreeable odor and taste, however,and many patients could not be induced to take it, while those whowere courageous enough to swallow it, often suffered from eructationand diarrhoea afterward. It may be added that none of these new preparations are superior to the nitrate in efficiency as disinfectants, and tiw that are less irritant zolpidem 10mg tablets are also less reliable.silver preparations ought not to be used for long periods, as argyna tebeen induced in three months and after the use of 1530 g. There have 10 mg ambien been numerous medical trials with propecia to determine it&8217;s effect on baldness, and generally it is accepted that propecia has a positive effect purchase generic zolpiem with paypal on arresting hair loss in a majority of men. This is certainly the case for the discovery offirstinclass drugs against diseases ambien controlled of which the biology is poorly understood.the disadvantage of the approach is that molecular design strategies that arebased on singular protein targets cannot be applied to optimise the activityand reduce the toxicity of the drug molecule.phenotypic screening was frequently applied in the 1970s to 1990s. The same reversalof effect by ergotoxine- is seen buy generic ambien in houston if the splanchnic nerves be stimulated. Figure 20-9 shows that at alow surfactant concentration and at low surface coverage, thehydrocarbon chains of the cheapest generic ambien online with visa adsorbed surfactant molecules lieflat against the solid surface. Sildenafil was not carcinogenicwhen administered to mice for 18-21 months at dosages up to the maximum tolerated dose(mtd) of 10 mg/kg/day, approximately 0.6 times the mrhd on a mg/m2basis.sildenafil was negative inin vitrobacterial and chinese hamster ovary cell assays to detectmutagenicity, andin vitrohuman lymphocytes andin vivomouse purchase generic zolpiem with paypal micronucleus assays to detectclastogenicity.there was no impairment of fertility in rats given sildenafil up to 60 mg/kg/day for 36 days tofemales and 102 days to males, a dose producing an auc value of more than 25 times thehuman male auc.there was no purchase generic zolpiem with paypal effect on sperm motility or morphology after single 100 mg oral doses of tabletin healthy volunteers.pregnancy, nursing mothers and pediatric usetablet is not indicated for use in purchase generic zolpiem with paypal newborns, children, or women.pregnancy category b.no evidence of teratogenicity, embryotoxicity or fetotoxicity wasobserved in rats and rabbits which receivedup to 200 mg/kg/day during organogenesis. Suppuration and even gangrene havebeen developed in a very considerable number of cases, and in otherssevere or purchase generic zolpiem with paypal fatal mercury poisoning has been observed. When thetvalue is significant, theprintout contains an estimate of the shelf life with the appropri-ate confidence interval. The heart seemed little affected, although thebloodpressure fell rapidly toward the end. Recently, however, there is again agrowing interest in phenotypic screening since this is a way of moving beyondwelldefined targets from the literature to discover new therapeutic targetsand new disease biology. Technically, no, you can buy without a prescription but purchase generic zolpiem with paypal you should have a prescription for your if you care about your erectile dysfunction and your health. It maybe injected in one or in several doses and as much as 3 c. These reports should aid the physician in selecting an antibacterial drug product for treatment. (courtesy of purchase generic zolpiem with paypal hosokowa micron powder systems.)figure 24-9. The tingle means the cold zolpidem 10 sore countdown is on. This is a journal of photographs for random found places, people and objects. However,it is possible, though remote, for both types of stability failuresto occur simultaneously within the same pharmaceutical prod-uct. Fdaa?s current analysis of data where to purchase ambien 10mg online with mastercard available to fda concerning this drug. For cases in which the slope of the best fitting line is posi-tive and significantly different from zero (resulting, e., fromsolvent evaporation), the statement “no degradation has beendetected and hence no shelf life estimate is made” is printed.when the computed line has a positive slope but not signifi-cantly different from zero, only the minimum shelf life value iscalculated.traditionally, extensive stability data are collected at therecommended storage temperatures (usually refrigerator and/or room temperature) to be placed on the label of the package.however, elevated-temperature data are very valuable in deter-mining the shelf life of a product. A comparison of volumetric and circumferential measures of penile erection. In clinical trials withtadalafil taken on demand for the treatment of erectile dysfunction, diarrhoea was reported morefrequently in patients over65 yearsof age. 603). Throughout the discussion so far, examples of surface-activeagents (surfactants) have been restricted primarily to fatty acids and their salts. Among purchase generic zolpiem with paypal these influencesis the temperature itself, for bkrbour has shown that the overheatedblood tends to change the activity of the centre so that the heat loss isaugmented.the antipyretics do not lower the temperature by reducing theheat production, for, though the nitrogen zolpidem from india eliminated and the oxygenabsorbed fall during their action in fever, this lessened tissue waste isthe result not the cause of the fall of temperature, the metabolismproceeding more slowly when the heat is reduced.calorimetric investigations have shown that the dissipation of heatin fever is much increased by the antipyretics, while in health theyseem purchase generic zolpiem with paypal to have little effect. Thus, exploiting interrelations benefits both sectors and purchase generic zolpiem with paypal reduces overall planning and forecasting burden. The prices are listed per tablet so, depending on the quantity you decide to buy, you can immediately see how much it will cost. The ointment is occasionally applied in skin diseases and to destroyparasites.unguentum hydrargyri nitratis (u.), citrine ointment, isused, diluted with oil or lard, in conjunctivitis, and also as an application tosyphilitic sores and gangrenous ulcers; it is acid and strongly irritant.unguentum hydrargyri citratis dilutum (b.), citrine ointment diluted toone part in five.a large number of new preparations of mercury have been introduced oflate years and have received a more or less extensive trial, but have seldombeen purchase generic zolpiem with paypal found to be superior to the older forms. This value is analogous cheapest generic ultram 100mg with paypal to the area under theblood concentration–time curve. Cross-sectional study of 102 consecutive women purchase generic zolpiem with paypal purchase generic zolpiem with paypal attending an urban gynecology clinic. At a purchase generic zolpiem with paypal certain moment in time during drug development, the chemical andpharmaceutical purchase generic zolpiem with paypal manufacturing process is developed to a level that it is readyfor transfer to a fullscale chemical and pharmaceutical manufacturing plant.this is a huge undertaking that involves different experts in chemical andpharmaceutical engineering, analytical chemistry, quality assurance, supplymanagement, production management, pharmaceutical formulation, finance and investment. In the light of recent work this argument falls to theground and the general view may be purchase generic zolpiem with paypal zolpidem dosage 10 mg stated that while digitalis may failto improve these cases, it has no deleterious effect on purchase generic zolpiem with paypal them. These ulcers arise from any abrasion of the skin, and thecartilaginous septum of the nose is also a common seat of ulceration, whicheventually leads to perforation. It has also been used in dilutesolution to preserve food, and a solution is often sprayed upon grapevines and other plants purchase generic zolpiem with paypal to preserve them from the purchase generic zolpiem with paypal attacks of insects.poisoning has occurred from these sources and is purchase generic zolpiem with paypal difficult to diagnose,as it is in some cases impossible to find the means by which the arsenicenters the system. Online pharmacy is an internetbased purchase generic zolpiem with paypal vendor of prescription drugs, and the term encompasses both legitimate andillegitimate pharmacies. For theaction of nicotine on the muscles is opposed by curara, not only innormal muscles, but also in those in which the nerves and nerve-endingshave degenerated through section. It seems to be equally, or according to some observers; morestro ngly antisep tic, and like salicylic acid ir ritate s the mucous, mem-branes, wh ile its salts are practically devoid of this last property.benzoic acid is, however, apparently l ess stimulant to the centra lnervous system, and the characteri stic aneetions ot the hearing andsi ght have not been observed under it. Brodin-sartorius and colleagues present a long-term study on the impact of cysteamine therapy on these complications. When cheapest generic zolpidem 10mg online legally from canada given in large quantities by the mouth it sometimescauses some diarrhoea in animals, but apart from this its only effect is glycosuria,which also follows its injection subcutaneously or intravenously. Monitoring as a qualitycontrol system during the conduct of clinical trials allows identification ofproblems early on and corrective actions and preventive actions (capas)to be suggested in order to do better in the future.