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Regardless of the source or the key idea leading to a drug candi-date buy cheap xanax 1mg in the uk online molecule, testing it involves a sequence of experimentationand characterization called drug screening. P450 substrates — is not expected to cause clinically significant is xanax legal to buy in cancadda inhibition or induction of the clearance of drugs metabolized by cytochrome p450 (cyp) isoforms. The number of specific examples of such drug-induced toxicity is expanding rapidly. In another clinicalpharmacology study tadalafil buy cheap xanax 1mg in the uk online (20mg) was studied in combination with buy cheap xanax 1mg in the uk online up to 4 classes ofantihypertensives. But these owe their use, not to the calciumion, but to the other part of the molecule — the anion. Thereafter, xanax 1mg prescription thailand 17 subjects were treated with tablet 25 mg or matching placebo incombination with doxazosin 4 mg (15 subjects) or doxazosin 8mg (2 subjects). Because a prime requisite for equilibriumis that the free energy of a system be at a minimum, it is notsurprising to observe that phases in contact tend to reduce areaof contact spontaneously.liquids, being mobile, may assume spherical shapes (smallest interfacial area for a given buy generic xanax 1mg in bangkok volume), as when ejected froman orifice into air or buy cheap xanax 1mg in the uk online when dispersed into another immiscibleliquid. Hcl . Patients should be counseled regarding the dosing of especially regarding the maximum daily dose. The first form arises from the muscular action, whichmay increase the excitability of the ventricle or auricle so much thatspontaneous beats (extrasy stoles) arise (fig. Tadalafil has no effect in the absence of sexual stimulationstudiesin vitrohave shown that tadalafil is a selective inhibitor of pde5. However,halothane, enflurane, and sevoflurane have little effect buy cheap xanax 1mg in the uk online on heartrate, probably because they attenuate cheapest alprazolam baroreceptor input into theautonomic nervous system. — quinine appears in the urine within a short time (15minutes) after its exhibition by the mouth, and it continues to beexcreted by the kidney in some quantity during the next twentv-fourhours, and in smaller amounts up to about seventy-two hours. Used locally in to yi per cent, solution to quiet pain, in 3to buy cheap xanax 1mg in the uk online buy cheap xanax 1mg in the uk online 6 per cent, solution to allow of surgical operation or examination by instruments. Conversely, spironolactone and other-retaining diuretics (e. Different cell types expressdifferent accessory proteins, which interact with steroid receptorsand change the functional effects of drug-receptor buy cheap xanax 1mg in the uk online interaction. Propecia reported that their bald spot got smaller, their hair loss slowed down, and the appearance of their hair improved. However, onlycritical data are shared with the drug development organisation, while confidential data that constitute the intellectual property of the active ingredient manufacturer have to be submitted directly to the authorities (ema or eumember states) by means of an active substance master file (asmf) [18].when a maa is submitted to the authorities, a letter from the manufacturerof the active ingredient is added stating that the confidential information wassubmitted by the manufacturer directly but separately from the dossier tothe authorities through an asmf. Some ofthese men continued in additional extension studies receiving propecia, with 290 men entering the fifthyear of the study (see figure below).hair counts were assessed by alprazolam 2mg prescription only photographic enlargements of a buy cheap xanax 1mg in the uk online representative area of active hair loss.in these two studies in men with vertex baldness, significant increases in hair count were demonstrated at6 and 12 months in men treated with propecia, while significant hair loss from baseline wasdemonstrated in those treated with placebo. The usual dose of is 10 milligrams (mg) taken no more than one time each day, one hour before sexual activity. Also, when soliddosage forms (e., tablets) are subjected to high temperatures,changes in the quantity of moisture in the product may greatlyinfluence the stability of the product.arrhenius buy cheap xanax 1mg in the uk online plots also suffer limitations buy cheap xanax 1mg in the uk online when applied to reactions that have relatively low activation energies and, therefore, are not accelerated greatly by an increase in temperature.where usually it is desirable to determine xanax buy online india drug stability byanalyzing samples for the amount of intact drug remaining—in instances where there is very little drug decomposition andparticularly when it is not convenient to accelerate the reaction by increasing temperature—it sometimes is advantageousto determine initial reaction rates from the determination ofthe amount buy cheap xanax 1mg in the uk online of reaction product formed.using modern methods of analysis, such as high-performanceliquid chromatography (hplc), buy cheap xanax 1mg in the uk online it is often possible to measurethe xanax 1.5mg online canada rate of formation of a degradation product. It is to benoted that on xanax prescription korea giving 0. Slight changes in temperature (1 or2°c) can affect the consistency of an ointment greatly; hence,rheological studies on ointments must be performed only atconstant and controlled temperatures.among the other tests performed during the stability study ofan ointment are a check of visual appearance, color, odor, vis-cosity, softening range, consistency, homogeneity, particle sizedistribution, and sterility. Its action is often beneficial and has been attributed to itsdepressing the buy cheap xanax 2mg online europe bronchial muscles, which are supposed to be in buy cheap xanax 1mg in the uk online a con-dition of spasmodic contraction in asthma. Seek immediate medical attention if you experience any of the following side effects: ultimately, however, the central nervoussystem, particularly the respiratory centre, is paralyzed as withconiine. In argyria no impfl vf "ment can be expected, though the iodide of potassium may be tried.f the bismuth swallowed is absorbed, but several authorities have found traces in the urine of patients treated with it internally, so that some evidently buy cheap xanax 1mg in the uk online buy cheap xanax 1mg in the uk online passes into the blood under certainunknown conditions. The drug is generaly largelyeliminated by vomiting, so that no further effects are observed.the nausea and vomiting are accompanied by the usual symptoms— muscular weakness and depression, increased secretion of saliva andof mucus by the buy cheap xanax 1mg in the uk online glands of the throat purchase sibutramine 15mg online india and respiratory passages, oftenperspiration and generally temporary acceleration of the pulse.quantities which are too small to provoke vomiting, induce pro-longed nausea with increased mucous order xanax 2mg mastercard secretion along the respiratorypassages and some perspiration.emetine possesses a powerful irritant local action, which is, how-ever, much more marked in buy cheap xanax 1mg in the uk online certain individuals than in others. In pregnant animalsabortion is often induced, but not invariably, even when very largedoses are given.in fowls a characteristic train of symptoms is induced, and theseanimals have frequently been used as tests for the activity of ergotpreparations. The minimum effective dose, the maximum tolerateddose, and the dose response (intermediate doses) also must bedetermined.if after phase ii the drug still looks promising, it is distributedmore widely to selected practicing physicians in the phase iiistudy. Dht and, in this manner, seems to break up the development of male pattern hair loss. A man is much moresusceptible to morphine than a dog, likewise one species of frogsdiffers from another in this buy cheap xanax 1mg in the uk online respect. 26) constantly transmits impulses through theciliary nerves to the sphincter muscle of the iris and keeps the pupilmoderately contracted, and when these impulses can no longer reachthe iris owing to the interruption of the path, the sphincter relaxesand the pupil dilates. The drug discovery process is discussed in more detail in chapter 2. This is thoughtto result from the combined effects of nitrates and tadalafil on the nitric oxide/cgmp pathway.therefore, administration of to patients who are using any form of organic nitrate iscontraindicated (see section 4. Penile prostheses are available in semi-rigid, self-contained 2-piece inflatable, and 3-piece inflatable buy cheap xanax 1mg in the uk online models. This isindeed the case of the furanocoumarins in grapefruit juice thatinactivate cyp3a4 in the intestinal mucosa and consequentlyenhance its proteolytic degradation. The glucosides vary considerably in their power of contractingthe vessels when thus perfused; digitoxin is distinctly more powerfulthan strophanthin in contracting them and has a more limited actionin dilating them. After awaking from morphine sleep,there may be noticed in man, more or less nausea or vomiting anddepression, and occasionally headache and excitement. Results in ed patients with diabetes mellitus — for once daily use was shown to be effective in treating ed in patients with diabetes mellitus. Even now, men do not perceive erectile dysfunction as a normal part of aging and seek to identify means by which they may return to their previous level and buy cheap xanax 1mg in the uk online range of sexual activities. It is currently providing data to other web parts, and these connections will be deleted if this web part is closed. Regulation of noncontact erection in rats by gonadal steroids. These structure-activity-relationships (sars) are fun-damental to drug discovery. The man squeezes the pump to buy cheap xanax 1mg in the uk online move fluid into the cylinders and cause them to become rigid. If, during the conduct of a clinical trial, patients experienceproblems with swallowing a tablet, pharmaceutical formulation buy cheap xanax 1mg in the uk online experts areinvolved to modify the pharmaceutical form to eliminate the problem. The moreimportant of these older drugs are ipecacuanha, tartar emetic (antimony),ammonium carbonate, the sulphates of copper, zinc and alum.vomiting is not now such an important method of treatment as itwas formerly, and buy cheap xanax 1mg in the uk online the emetics are less frequently employed to evacuatethe stomach than other less heroic measures, buy drug alprazolam 2mg online such as the passage ofthe stomach tube. Do not take in larger or smaller amounts or for longer than recommended. It is for this reason that in spite of theclaim of manufacturers, all are prone to produce impleasantsymptoms on awaking just as after having taken an excess ofalcohol, and instead of feeling refreshed patients frequently feeltired, dizzy, nauseated, etc.the most powerful, rapidly acting and reliable is chloral. Andcontaining r j ff gr.

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The strongacid (aqua regia) is the most powerful solvent and oxidizing agent known,dissolving such refractory metals as platinum and gold.the diluted acid alone is used in therapeutics (dose 15 mins.) and has somereputation in liver diseases and jaundice. This process of postapproval activities is the last and major stepin the process of a drug life cycle. More buy cheap xanax 1mg in the uk online recently, there was introduced a crystallinemixtiure of all the alkaloids of opium called pantopon with thedaim that it was much more efficient than crude opium or anysingle one of buy cheap xanax 1mg in the uk online its alkaloids. It seems to be equally, or according to some observers; morestro ngly antisep tic, and like salicylic acid ir ritate s the mucous, mem-branes, wh ile its salts are practically devoid of this last property.benzoic acid is, however, apparently l ess stimulant to the 2mg xanax bars high centra lnervous system, and the characteri stic aneetions ot the hearing andsi ght have not been observed under it. In well diluted vapor the symptoms of exaltation aloneare observed, no anaesthesia following. Phloridzin may bedecomposed into a sugar, phlorose, and phloretin, which also induces glycosuria.the most typical example of salt-action is presented by chloride ofsodium, for this salt is always present in large quantities in the body,and has practically no specific action; the sodium and chloride ionsare ordinary and necessary constituents of the fluids of the body. The drugs and cosmetics act, 1940, and buy cheap xanax 1mg in the uk online the drugs and cosmetics rules, 1945, have clear guidelines on the sale ofschedule h and schedule x drugs, which are œrestrictive drugs and can be sold only buy cheap xanax 1mg in the uk online on the prescription of a registeredmedication practitioner (sharma, 2015). The heart maybe temporarily slowed cheap xanax no prescription by inhibitory reflexes. Cinchonineand cinchonidine are isomeric (c19h22n2o) and perhaps contain twoquinoline molecules, while buy cheap xanax 1mg in the uk online quinine and quinidine (c20h24n2o2) aremethoxyl compounds of cinchonine. This generally sets in suddenly, andis accompanied in most cases by obstinate constipation, in a very smallproportion by diarrhoea. Potential drug candidates are examined earlyon for specificity against other unrelated molecules, a meansof reducing side-effects in individuals. On the contrary, othersshow a very strong stimulation of the pneumogastric, whichmay make the pulse dangerously slow.although the force of buy generic xanax 1mg online the pulse is raised by digitoxin in thepresence of paralysis of the blood vessel walls, xanax 1mg prescription korea yet it is possiblethat under normal conditions the vasomotor system is stimulated centrally want to buy alprazolam 1mg online india and peripherally and that this condition assistsin the raising of the arterial tension. The combined use of sex therapy and intrapenile injections in the treatment of impotence. Examplesdiscussed in this book include: buy cheap xanax 1mg in the uk online Once the cold sore has broken through the skin, healing can take up to 10 to 12 days. They are formed of brown resinous masses andcontain the neutral prindple aloin, xanax pills buy them online in united states emodin and a resin.extractum aloes (u.p,). The quantity eliminated daily risesslowly during the buy cheap xanax 1mg in the uk online treatment and then falls gradually. When ananimal infected with trypanosomes is treated with arsenic, the parasites oftendisappear from the blood for some days or weeks and then reappear, but canagain be expelled by arsenic, though for a shorter time; this phenomenon ofdeveloped tolerance is better known when these organisms are treated withorganic arsenic compounds and will be discussed there (p. Sometimes,in warmblooded animals depression of the cerebrum with sleepfollowing, but in very low organisms depression of the buy cheap xanax 1mg in the uk online entire nervous system is almost the only action. Dysfunction - your choices introduction impotence is a common condition. The use of this antitoxic serum may thus pro-tect animals from the toxin of a disease, provided it be administeredearly. Two additionaltasks must be accomplished before a clinical trial can be un-dertaken. Erythrophlceineand a more recently isolated alkaloid, muawine, which resembles it in mostrespects, split off a molecule of sugar when they are boiled with acids. And aremuch weaker after division of the cord immediately below the medullathan in the intact animal. A major study in britain by taylor nelson research (1990) found that consumersusually recall fewer than 3 messages from an advertisement. Recovery hasbeen observed after very large quantities, while in other cases 0.(2 grs.chronic antimonial poisoning is very rare and difficult buy cheap xanax 1mg in the uk online to diagnose. The lessenedactivity of the narcotised buy cheap xanax 1mg in the uk online centre buy cheap xanax 1mg in the uk online leads to a less active constriction of theskin vessels and thus to a larger loss of heat. This causesa small rise in the blood-pressure, and another factor leading to the same resultis a slight constriction of the arterioles through a direct action on the muscularcoats; this slight constriction is observed also on perfusing the survivingorgans. If you are over 65 years of age, you may be more likely to experience side effects from sildenafil. It is probably due to directaction on the retinal cells, as it xanax prescription regulations is more marked if strychnineis injected subcutaneously in the buy cheap xanax 1mg in the uk online neighborhood of the eye,and the eflfect is seen best on the one near where the injectionhas been made. In solid form, takeninternally, it may produce reddening and superficial corrosionof the mucous membranes of the gastrointestinal tract, but theseeffects are never to be seen from diluted solutions or. When there is no buy cheap xanax 1mg in the uk online buy cheap xanax 1mg in the uk online organic factor and the problem lies purely in the mind, it is labeled a case of psychogenic impotence. Iead smelters, workers in white lead factories, painterplumbers, buy cheap xanax 1mg in the uk online electricians, and typesetters are liable to lead poisonifl?from continually handling the metal; but other trades are not exemptfrom it, and sometimes the channels by which it gains entrance to thebody are very obscure. We have compared plastic and the super heavy weight steel (3 lbs each) signs and license plates, as well as the very ultra thin lightweight aluminum embossed and non-embossed signs. It is absorbed veryslowly from the intestine like the other alkaline earths, and is deposited insmall quantities in the bones buy cheap xanax 1mg in the uk online of growing animals, especially when there is adeficiency of lime in the food; but it cannot be used to replace the calciumof the food, animals treated thus buy drug xanax in the uk online showing the symptoms of lime starvation. Erectile dysfunction (ed) medicine clinically proven to both go to work fast, in as little as 30 minutes for some men, and work up to 36 hours.

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—i.mesotan (methoxymethylester of salicylic add), greenish liquid almostodorless, and easily absorbed by the skin. Distinguishing buy cheap xanax 1mg in the uk online between organogenic and psychogenic erectile dysfunction. Alternatively,bile salt and lecithin based micelles buy cheap xanax 1mg in the uk online can be used such as taurocholate (tc),taurodeoxycholate (tdc), and deoxycholate (dc). The acceleration is the result of the fall in pressurelessening the supply of blood to the brain and arousing the respiratorycentre. Cder is also responsiblefor the assessment of drugs submitted for registration of a clinical trialapplication and during the clinical trial in the buy generic xanax form of an investigational newdrug (ind) application and the application for marketing authorisationin the form of a new drug application (nda). Although physical causes are now more readily diagnosed and treated, individual or marital counseling is still an effective treatment for impotence when emotional factors buy cheap xanax 1mg in the uk online play a role. Thus, when aconitine isswallowed, the prickling and warmth is felt in the lips, tongue andthroat, and after small doses may be confined to xanax cod these parts, while ifan ointment containing aconitine be rubbed on the skin, the same sen-sation is induced locally. Allergic reactionsto benzodiazepines are rare to nonexistent.clinical uses dosagebenzodiazepines are most commonly used for preoperative medi-cation, intravenous sedation, and suppression of seizure activity.less frequently, midazolam and diazepam may also be used toinduce general anesthesia. In the competitivemarkets of today, it is critical to improve quality and servicecontinually while minimizing costs and maximizing resourceutilization to help contain overall healthcare costs. Pde5 inhibitors, tadalafil has mild systemic vasodilatory properties that may result in transient decreases in blood pressure. The respiration should be stimulated byrespiratory stimulants, and, if necessary, artificial respirationshould be performed. It is excreted in theurine, the bile, the secretion of the intestinal epithelium, in the milkand saliva, cheapest place to buy ultram 50 mg and in traces in the perspiration.chronic lead poisoning is the commonest of all forms of metallifpoisoning, and at the same time one of the most insidious. Both glass and plasticcontainers are used to protect light-sensitive formulations fromdegradation. Contrast the effects of inhibition alonein figs. Some other members of the aromatic series are useful inthis condition, but none are superior to the salicylic preparations inefficacy. The comparison of the iron in the food and in drugs with thatof the stools therefore gives no clue as to how much has been absorbedand how much has buy cheap xanax 1mg in the uk online simply passed through the intestine.but the passage of iron from the liver to the intestine is a somewhatslow process, and it is therefore possible to detect the excess of iron inthe liver. As a purge and intestinal disinfectantit is of value in biliousness and in the diarrhoea of putrefaction, less so in buy cheap xanax 1mg in the uk online diseasesin which the intestinal wall is the site of infection, as in typhoid fever andcholera. These guidelines provide the basis forthe harmonisation of the interpretation and application of the detailedrequirements to demonstrate the quality, safety and efficacy of the new drug.although these guidelines offer guidance and cannot be legally enforced,the ema encourages marketing authorisation applicants to follow them.the ema strongly advises the applicants of a regulatory dossier either a the food and drug administration (fda) is responsible forprotectingpublic health through the safety, efficacy and protection of human andveterinary drugs, biological products, food supplies, cosmetics and irradiatedproducts, for protecting public health by fasttracking innovations that makedrugs and food safer, more effective and more available to the populationand for communicating correct scientific information on drugs and food.the agency issuesguidances or guidelines on very different topics of drugdevelopment and has a specialised department for new drug assessment.this division is thecenter for drug evaluation and research (cder).every year it publishes new, revised and/or draft guidances. Multiple-dose vials should be buy cheap xanax 1mg in the uk online stored in a dark place.manufacturers of prescription drug products should includesufficient information on their product labels to inform thepharmacist of the type of dispensing container needed to main-tain the identity, purchase xanax with visa strength, quality, buy cheap xanax 1mg in the uk online and purity of the product.this brief description of the proper container, such as light- re-sistant, well-closed, or tight, may be omitted for those productsdispensed in the manufacturer’s original container. It consists of different phenols, as carbolicadd and thymol, creosote, naphthalene and its derivatives,benzoic acid and ichthyol.phenol. The symptoms of acute metallic poisoning elicited thusin animals generally resemble fairly closely those of chronic poisoningin man. Peak plasma concentrations increase with increasing dose but times-to­peak do not differ among doses. Beside the threedevelopment streams, other areas of expertise are essential in drug development such as regulatory affairs, quality management, process management,project management, clinical trial management and data management.in the end, the drug development team has to provide an answer to threepivotal questions these questions are addressed by buy cheap xanax 1mg in the uk online the chemical/pharmaceutical, nonclinicaland clinical team members, respectively. Before such decisionsare taken an internal review process is initiated to make sure that all dataneeded for the next step are available and that they buy generic alprazolam online india are of the requiredquality. Thisproperty is usually masked by its stimulation of the sympatheticnervous system but may become apparent in critically ill buy cheap xanax 1mg in the uk online patientswith limited ability to increase their sympathetic nervous systemactivity. Paint and took the colour pixels from aqua and took the pixel from blue. Malignant hyperthermia malignant hyperthermia is aheritable genetic disorder of skeletal muscle that occurs in susceptibleindividuals exposed to volatile buy cheap xanax 1mg in the uk online anesthetics while undergoing gen-eral buy cheap xanax 1mg in the uk online anesthesia.olarizingmuscle relaxant succinylcholine may also trigger malignant hyper-thermia. Psychological characteristics of males with secondary erectile failure. After the emergency has passed, thedose buy cheap xanax 1mg in the uk online of digitalis necessary to keep the pulse fairly low is found bygradually reducing the daily dose, and this amount may have to betaken for a long time or even taken at intervals throughout life, forthe underlying condition of auricular fibrillation persists in spite of alltreatment.in other forms of heart disease the effects of digitalis are less spec-tacular than purchase xanax 1.5mg online legally cheap in auricular fibrillation, and although improvement un-doubtedly results from the treatment, there is no such guide as is offeredby the slowing of the pulse in fibrillation. During sexual activity, if you become dizzy or nauseated, or have pain, numbness, or tingling in your chest, arms, neck, or jaw, stop buy cheap xanax 1mg in the uk online and call your doctor xanax 1.5mg prescription uk right away. Systematic review of literature based buy cheap xanax 1mg in the uk online on a search strategy (2000-10) in medline, embase, cochrane library, crd, ecri, and hayes. Com-plete local anaesthesia is obtained, and shock is buy cheap xanax 1mg in the uk online less liable to occurthan when general anaesthesia is induced (crile). The term erectile dysfunction covers a range of disorders, but usually refers to the inability to obtain an adequate erection for satisfactory sexual activity. Itsphysicochemical properties, such as solubility and dissociationconstant, and it should be effective against buy cheap xanax 1mg in the uk online a wide spectrum ofmicro-organisms, stable for its shelf life, nontoxic, nonsensitizing, compatible with the ingredients in the dosage form, inexpensive, and relatively free of taste and odor.the chosen preservative should be sufficiently stable and soluble to achieve adequate concentration to buy cheap xanax 1mg in the uk online provide protection.this choice is more critical in two and three phase emulsiontable 24-1. Success ismore uncertain when non-homogeneous products are involved.suspensions of drugs may not provide linear arrhenius plotsbecause often there is the possibility that the solid phase, whichexists at elevated temperature, may not be the same solid phasethat exists at room temperature. More recently, there was introduced a crystallinemixtiure buy cheap alprazolam 1.5mg online with paypal of all the alkaloids of opium called pantopon with thedaim that it was much more efficient buy cheap xanax 1mg in the uk online than crude opium or anysingle one of its alkaloids. The (3-methyl group(methacholine, bethanechol) reduces the potency of these drugs atnicotinic receptors (table 7-2).the tertiary natural cholinomimetic alkaloids (pilocarpine,nicotine, lobeline; figure buy cheap xanax 1mg in the uk online 7-3) are well absorbed from most sitesof administration. As aluminum purchase generic xanax 2mg tablets online is ableto withstand the high temperatures required to cure epoxy andphenolic resins adequately, tubes made from this metal pres-ently offer the widest range of lining possibilities.closure fold seals may consist of unmodified vinyl resin orplasticized cellulose and resin, with or without added alprazolam 1.5mg paypal color.collapsible tubes are available in many buy generic xanax in florida combinations ofdiameters, lengths, openings, and caps. At first, it only causesa dilatation of the superficial vessels, especially those of the faceand upper part of the body, so that the skin becomes hot, reddened, suffused, and covered with perspiration; buy cheap xanax 1mg in the uk online it also dilatesgroup of amyl nitrite. The intestine relaxes, while theuterus contracts powerfully.when it is injected hypodermically, the skin and buy cheap xanax 1mg in the uk online subcutaneous tissuesaround the point of injection become pale and anaemic and may be cutinto without bleeding, and when it is applied to a bleeding surface, thehaemorrhage is arrested unless some large artery has alprazolam 1mg prescription probation been opened. The gas evaporates rapidly from its watery solutions,and the carbonate gives off ammonia buy cheap xanax 1mg in the uk online freely, so that the effects arevery similar, although the solution of ammonia is much the morepowerful. This dilatation is partly owing buy cheap xanax 1mg in the uk online to theincreased pressure in the interior overcoming the contraction of the walls,but is mainly to be ascribed to an imperfect compensatory action of the vaso-motor centre.